TBDMS or TBS Ether Deprotection with TBAF & AcOH

TBS or the TBDMS protection is a very versatile one for  primary and secondary alcohols. Here we used it to selectively protect a cyclopentanol and then did some chemistry at the adjacent to get acetyl group there. Next, we need to remove this Silyl ether protection so that we can get the desired product in the reaction below. We tried […]

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Hydrolysis Reaction Setup

Here is a setup of reaction for hydrolysis of a methyl ester using Sodium hydroxide at 60 degree Celsius. The ester is methoxy methyl acrylate. We were required to get this acid after the hydrolysis so that we can convert it to acid chloride and finally to isocyanate.   The isocyanate is then reacted with the amine counterpart to complete […]

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A Deprotection Reaction Setup

Here is a setup of the deprotection reaction. The reagent is being added using a dropping funnel while the reactant or the starting material is stirred magnetically in an ice bath. In the dropping funnel is a solution of sodium methoxide which is going to deprotect the benzoyl protection in the starting material. This reaction is color sensitive. you can […]

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Preparing a filter (fluted) paper funnel

Hello Buddies! I know every chemist now and then needs to filter something. And you use filter paper either stand alone or with a glass or plastic funnel. Usually there is some problems in getting a filter paper funnel that fits well in a glass/plastic funnel. Here we are going to show you a strong filter paper funnel preparation that […]

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Acetonide Protection: A Versatile Approach on Diols

Preparation of Acetonides Acetonide protection is the most commonly used protecting strategy for vicinal diols in organic synthesis. This is an acid labile protection which means that it can be removed to regenerate the diol in presence of acid. This is also a very cost effective procedure as this requires a very common organic solvent and in most of the […]

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m-CPBA Oxidation and removal of CBA (Chloro Benzoic Acid)

 2-Chloro benzoic acid or m-CPBA is most commonly used reagent for N-oxidation and epoxidation reaction. We were doing an epoxidation with this reagent on a double bond on cyclopentyl ring. We made an interesting observation on face selectivity. We had some interesting observations: The orientation of the epoxide ring depends highly on the substitutions of the ring. certain Solvent Systems can turn the orientation, […]

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Download Chemdraw Ultra 12.0 for Free

Cambridgsoft has been acquired by Perkin Elemer and the latest version of Chemdraw is only available through their website. It costs a lot for a an student. Still, you can try the new released version of ChemDraw 12.0 for free. To do that you need to download it via utorrent. So, first download and install the uTorrent and then download the  following […]

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