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Jul 15

Conversion of Amine to Ketone

This is an important but less studied transformation of functional group in organic synthesis. This kind of reaction can go via imine formation which in turn is hydrolyzed to give ketone.

Amine to Ketone

Imine formation itself could be a two step process starting from N-halogenation followed by dehydrohalogenation using strong base.

Imine can be hydrolyzed using strong acids such as Sulfuric Acid at pH 2 to give corresponding Ketone from cyclic primary amines.

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